Drug interactions
Desvenlafaxine + Lsd
Severity: Major
Desvenlafaxine and Lsd: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Serotonergic reuptake inhibitors alter the response to LSD, usually blunting its effects, and the combination has also been associated with serotonin toxicity and unpredictable psychiatric reactions. LSD is an illicit substance with no approved clinical use outside research.
What this interaction means in plain words
Desvenlafaxine and Lsd can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
LSD is a serotonin receptor agonist with additive serotonergic effects alongside SNRI reuptake inhibition, with receptor adaptation also altering the response.
What to do
Advise patients to avoid LSD during desvenlafaxine therapy. Treat suspected serotonin syndrome with supportive care and benzodiazepines, and stop serotonergic agents.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Frequently asked questions
Can I take Desvenlafaxine with Lsd?
MediHelp rates the interaction as major. Desvenlafaxine and Lsd can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Serotonergic reuptake inhibitors alter the response to LSD, usually blunting its effects, and the combination has also been associated with serotonin toxicity and unpredictable psychiatric reactions. LSD is an illicit substance with no approved clinical use outside research.
How serious is the interaction between Desvenlafaxine and Lsd?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid LSD during desvenlafaxine therapy. Treat suspected serotonin syndrome with supportive care and benzodiazepines, and stop serotonergic agents.
What other medicines interact with Desvenlafaxine?
MediHelp also lists interactions of Desvenlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Desvenlafaxine page.
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