Drug interactions
Desvenlafaxine + Metoclopramide intranasal
Severity: Moderate
Desvenlafaxine and Metoclopramide intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide is associated with extrapyramidal symptoms and rare serotonin syndrome and neuroleptic malignant syndrome, and serotonergic antidepressants may add to these risks. Antidepressants can also worsen dopamine antagonist movement disorders.
What this interaction means in plain words
Desvenlafaxine and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Central dopamine D2 blockade combined with serotonergic activity produces additive neurological toxicity; the mechanism is not fully established.
What to do
Use the lowest effective metoclopramide dose for the shortest time and monitor for tremor, rigidity, akathisia, hyperthermia and mental status change. Consider an alternative antiemetic if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Frequently asked questions
Can I take Desvenlafaxine with Metoclopramide intranasal?
MediHelp rates the interaction as moderate. Desvenlafaxine and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide is associated with extrapyramidal symptoms and rare serotonin syndrome and neuroleptic malignant syndrome, and serotonergic antidepressants may add to these risks. Antidepressants can also worsen dopamine antagonist movement disorders.
How serious is the interaction between Desvenlafaxine and Metoclopramide intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective metoclopramide dose for the shortest time and monitor for tremor, rigidity, akathisia, hyperthermia and mental status change. Consider an alternative antiemetic if symptoms appear.
What other medicines interact with Desvenlafaxine?
MediHelp also lists interactions of Desvenlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Desvenlafaxine page.
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