Drug interactions
Desvenlafaxine + Midazolam intranasal
Severity: Moderate
Desvenlafaxine and Midazolam intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midazolam is a sedative that depresses the CNS and respiration, and desvenlafaxine may add some CNS effects. Desvenlafaxine is only a weak CYP3A4 inhibitor, so the rise in midazolam exposure is likely small. The principal concern is additive sedation and, rarely, respiratory depression.
What this interaction means in plain words
Desvenlafaxine and Midazolam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, with possible slight CYP3A4 inhibition raising midazolam levels.
What to do
Monitor sedation level and respiratory status after intranasal midazolam. Make sure resuscitation equipment is accessible and observe the patient until recovered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Frequently asked questions
Can I take Desvenlafaxine with Midazolam intranasal?
MediHelp rates the interaction as moderate. Desvenlafaxine and Midazolam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Midazolam is a sedative that depresses the CNS and respiration, and desvenlafaxine may add some CNS effects. Desvenlafaxine is only a weak CYP3A4 inhibitor, so the rise in midazolam exposure is likely small. The principal concern is additive sedation and, rarely, respiratory depression.
How serious is the interaction between Desvenlafaxine and Midazolam intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and respiratory status after intranasal midazolam. Make sure resuscitation equipment is accessible and observe the patient until recovered.
What other medicines interact with Desvenlafaxine?
MediHelp also lists interactions of Desvenlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Desvenlafaxine page.
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