Drug interactions
Desvenlafaxine + Remimazolam
Severity: Moderate
Desvenlafaxine and Remimazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Remimazolam is a benzodiazepine sedative, and other CNS-active drugs may add to its sedative and respiratory depressant effects. Desvenlafaxine has modest sedative properties, so the interaction is mainly relevant if opioids or other sedatives are also given.
What this interaction means in plain words
Desvenlafaxine and Remimazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desvenlafaxine belongs to Central Nervous System; Remimazolam belongs to Central Nervous System.
Why it happens
Additive central nervous system depression.
What to do
Titrate remimazolam carefully and monitor oxygenation, respiratory rate and consciousness continuously during sedation and recovery. Have airway support available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Other interactions of Remimazolam
Frequently asked questions
Can I take Desvenlafaxine with Remimazolam?
MediHelp rates the interaction as moderate. Desvenlafaxine and Remimazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Remimazolam is a benzodiazepine sedative, and other CNS-active drugs may add to its sedative and respiratory depressant effects. Desvenlafaxine has modest sedative properties, so the interaction is mainly relevant if opioids or other sedatives are also given.
How serious is the interaction between Desvenlafaxine and Remimazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate remimazolam carefully and monitor oxygenation, respiratory rate and consciousness continuously during sedation and recovery. Have airway support available.
What other medicines interact with Desvenlafaxine?
MediHelp also lists interactions of Desvenlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Desvenlafaxine page.
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