Drug interactions
Desvenlafaxine + Same
Severity: Moderate
Desvenlafaxine and Same: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
S-adenosylmethionine (SAMe) may have serotonergic activity, and combination with serotonergic antidepressants has been linked to serotonin syndrome in case reports. Evidence is limited.
What this interaction means in plain words
Desvenlafaxine and Same can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive serotonergic effects, as SAMe may raise monoamine neurotransmitter levels.
What to do
Advise patients to avoid SAMe unless supervised and monitor for serotonin toxicity. Stop SAMe if agitation, tremor, sweating or fever develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Frequently asked questions
Can I take Desvenlafaxine with Same?
MediHelp rates the interaction as moderate. Desvenlafaxine and Same can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. S-adenosylmethionine (SAMe) may have serotonergic activity, and combination with serotonergic antidepressants has been linked to serotonin syndrome in case reports. Evidence is limited.
How serious is the interaction between Desvenlafaxine and Same?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid SAMe unless supervised and monitor for serotonin toxicity. Stop SAMe if agitation, tremor, sweating or fever develop.
What other medicines interact with Desvenlafaxine?
MediHelp also lists interactions of Desvenlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Desvenlafaxine page.
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