Drug interactions
Desvenlafaxine + Sumatriptan intranasal
Severity: Moderate
Desvenlafaxine and Sumatriptan intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triptans combined with SNRIs have been reported to cause serotonin syndrome, although the absolute risk is low. The combination is commonly used in migraine patients with comorbid depression.
What this interaction means in plain words
Desvenlafaxine and Sumatriptan intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects from 5-HT1B/1D agonism with serotonin and norepinephrine reuptake inhibition.
What to do
Use may continue with counselling about serotonin syndrome symptoms. Reassess if agitation, tremor, diarrhea or hyperthermia occur, especially after dose increases.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Frequently asked questions
Can I take Desvenlafaxine with Sumatriptan intranasal?
MediHelp rates the interaction as moderate. Desvenlafaxine and Sumatriptan intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triptans combined with SNRIs have been reported to cause serotonin syndrome, although the absolute risk is low. The combination is commonly used in migraine patients with comorbid depression.
How serious is the interaction between Desvenlafaxine and Sumatriptan intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use may continue with counselling about serotonin syndrome symptoms. Reassess if agitation, tremor, diarrhea or hyperthermia occur, especially after dose increases.
What other medicines interact with Desvenlafaxine?
MediHelp also lists interactions of Desvenlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Desvenlafaxine page.
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