Drug interactions
Desvenlafaxine + Trifluoperazine
Severity: Moderate
Desvenlafaxine and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desvenlafaxine is a weak CYP2D6 inhibitor, which at higher doses may modestly raise concentrations of CYP2D6 substrates. Trifluoperazine is partly metabolized by CYP2D6, so extrapyramidal effects, sedation or QT effects could increase. The effect is usually small at standard desvenlafaxine doses.
What this interaction means in plain words
Desvenlafaxine and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Weak inhibition of CYP2D6 by desvenlafaxine may reduce the metabolism of trifluoperazine.
What to do
Monitor for extrapyramidal symptoms, sedation and orthostasis. Consider a lower trifluoperazine dose if adverse effects appear, particularly with high desvenlafaxine doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Frequently asked questions
Can I take Desvenlafaxine with Trifluoperazine?
MediHelp rates the interaction as moderate. Desvenlafaxine and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Desvenlafaxine is a weak CYP2D6 inhibitor, which at higher doses may modestly raise concentrations of CYP2D6 substrates. Trifluoperazine is partly metabolized by CYP2D6, so extrapyramidal effects, sedation or QT effects could increase. The effect is usually small at standard desvenlafaxine doses.
How serious is the interaction between Desvenlafaxine and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms, sedation and orthostasis. Consider a lower trifluoperazine dose if adverse effects appear, particularly with high desvenlafaxine doses.
What other medicines interact with Desvenlafaxine?
MediHelp also lists interactions of Desvenlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Desvenlafaxine page.
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