Drug interactions
Desvenlafaxine + Vorapaxar
Severity: Moderate
Desvenlafaxine and Vorapaxar: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorapaxar is an antiplatelet drug that raises bleeding risk. Desvenlafaxine impairs platelet serotonin uptake and can also increase bleeding tendency. Combined use may increase the risk of bruising and gastrointestinal or other bleeding.
What this interaction means in plain words
Desvenlafaxine and Vorapaxar can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive impairment of platelet function: PAR-1 antagonism with reduced platelet serotonin uptake.
What to do
Monitor for signs of bleeding and review the need for other agents that raise bleeding risk. Consider gastroprotection in patients with a history of GI bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Frequently asked questions
Can I take Desvenlafaxine with Vorapaxar?
MediHelp rates the interaction as moderate. Desvenlafaxine and Vorapaxar can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vorapaxar is an antiplatelet drug that raises bleeding risk. Desvenlafaxine impairs platelet serotonin uptake and can also increase bleeding tendency. Combined use may increase the risk of bruising and gastrointestinal or other bleeding.
How serious is the interaction between Desvenlafaxine and Vorapaxar?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and review the need for other agents that raise bleeding risk. Consider gastroprotection in patients with a history of GI bleeding.
What other medicines interact with Desvenlafaxine?
MediHelp also lists interactions of Desvenlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Desvenlafaxine page.
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