Drug interactions
Devil's claw + Ibuprofen
Severity: Minor
Devil's claw and Ibuprofen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Devil's claw (Harpagophytum procumbens) is used for pain and has been reported to have possible antiplatelet effects and gastric effects. Combined with ibuprofen, additive bleeding and GI risk is theoretical.
What this interaction means in plain words
Devil's claw and Ibuprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive antiplatelet effect; mechanism not firmly established.
What to do
Advise patients to report GI upset or bleeding, and avoid using both for the same indication.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Devil's claw with Ibuprofen?
MediHelp rates the interaction as minor. Devil's claw and Ibuprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Devil's claw (Harpagophytum procumbens) is used for pain and has been reported to have possible antiplatelet effects and gastric effects. Combined with ibuprofen, additive bleeding and GI risk is theoretical.
How serious is the interaction between Devil's claw and Ibuprofen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to report GI upset or bleeding, and avoid using both for the same indication.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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