Drug interactions
Dexamethasone + Diltiazem
Severity: Minor
Dexamethasone and Diltiazem: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem may increase systemic dexamethasone exposure, strengthening corticosteroid effects. Dexamethasone may in turn modestly induce CYP3A4 and lower diltiazem levels.
What this interaction means in plain words
Dexamethasone and Diltiazem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexamethasone belongs to Endocrine; Diltiazem belongs to Cardiovascular.
Why it happens
Diltiazem inhibits CYP3A4 metabolism of dexamethasone.
What to do
Usually no change is needed; monitor for corticosteroid adverse effects with prolonged therapy and for diltiazem effect.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Frequently asked questions
Can I take Dexamethasone with Diltiazem?
MediHelp rates the interaction as minor. Dexamethasone and Diltiazem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Diltiazem may increase systemic dexamethasone exposure, strengthening corticosteroid effects. Dexamethasone may in turn modestly induce CYP3A4 and lower diltiazem levels.
How serious is the interaction between Dexamethasone and Diltiazem?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Usually no change is needed; monitor for corticosteroid adverse effects with prolonged therapy and for diltiazem effect.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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