Drug interactions
Dexamethasone + Haemophilus influenzae type b vaccine
Severity: Moderate
Dexamethasone and Haemophilus influenzae type b vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Immunosuppressive doses of corticosteroids may blunt the antibody response to Hib vaccination. Protection may therefore be suboptimal.
What this interaction means in plain words
Dexamethasone and Haemophilus influenzae type b vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Corticosteroid immunosuppression reduces vaccine immune response.
What to do
Vaccinate before starting immunosuppressive therapy when possible. Revaccinate after immune competence is restored if vaccinated during therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Frequently asked questions
Can I take Dexamethasone with Haemophilus influenzae type b vaccine?
MediHelp rates the interaction as moderate. Dexamethasone and Haemophilus influenzae type b vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Immunosuppressive doses of corticosteroids may blunt the antibody response to Hib vaccination. Protection may therefore be suboptimal.
How serious is the interaction between Dexamethasone and Haemophilus influenzae type b vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before starting immunosuppressive therapy when possible. Revaccinate after immune competence is restored if vaccinated during therapy.
What other medicines interact with Dexamethasone?
MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Mifepristone, Rilpivirine. The full list is on the Dexamethasone page.
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