Drug interactions
Dexamethasone + Hepatitis a / typhoid vaccine
Severity: Moderate
Dexamethasone and Hepatitis a / typhoid vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids may reduce the immune response to inactivated hepatitis A and parenteral typhoid vaccines. Protection for travel may be less reliable.
What this interaction means in plain words
Dexamethasone and Hepatitis a / typhoid vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Glucocorticoid-mediated immunosuppression reduces antibody production after vaccination.
What to do
Vaccinate early enough before travel and preferably before prolonged steroid therapy. Reinforce food and water precautions if the patient is on immunosuppressive doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Frequently asked questions
Can I take Dexamethasone with Hepatitis a / typhoid vaccine?
MediHelp rates the interaction as moderate. Dexamethasone and Hepatitis a / typhoid vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids may reduce the immune response to inactivated hepatitis A and parenteral typhoid vaccines. Protection for travel may be less reliable.
How serious is the interaction between Dexamethasone and Hepatitis a / typhoid vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate early enough before travel and preferably before prolonged steroid therapy. Reinforce food and water precautions if the patient is on immunosuppressive doses.
What other medicines interact with Dexamethasone?
MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Mifepristone, Rilpivirine. The full list is on the Dexamethasone page.
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