Drug interactions
Dexamethasone + Hydroxyprogesterone caproate
Severity: Minor
Dexamethasone and Hydroxyprogesterone caproate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone may induce CYP3A4 and lower hydroxyprogesterone caproate levels. The clinical relevance is uncertain.
What this interaction means in plain words
Dexamethasone and Hydroxyprogesterone caproate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
CYP3A4 induction by dexamethasone may increase metabolic clearance of hydroxyprogesterone caproate.
What to do
No routine adjustment is needed; monitor for reduced therapeutic effect in prolonged combined use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Frequently asked questions
Can I take Dexamethasone with Hydroxyprogesterone caproate?
MediHelp rates the interaction as minor. Dexamethasone and Hydroxyprogesterone caproate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dexamethasone may induce CYP3A4 and lower hydroxyprogesterone caproate levels. The clinical relevance is uncertain.
How serious is the interaction between Dexamethasone and Hydroxyprogesterone caproate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for reduced therapeutic effect in prolonged combined use.
What other medicines interact with Dexamethasone?
MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Mifepristone, Rilpivirine. The full list is on the Dexamethasone page.
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