Drug interactions
Dexamethasone + Indinavir
Severity: Moderate
Dexamethasone and Indinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir can raise dexamethasone exposure, increasing risk of corticosteroid adverse effects. Dexamethasone may also reduce indinavir levels.
What this interaction means in plain words
Dexamethasone and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Indinavir inhibits CYP3A4 and P-gp, decreasing dexamethasone clearance, while dexamethasone induces CYP3A4.
What to do
Monitor for steroid adverse effects and HIV virologic response; consider a lower dexamethasone dose or shorter course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Frequently asked questions
Can I take Dexamethasone with Indinavir?
MediHelp rates the interaction as moderate. Dexamethasone and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir can raise dexamethasone exposure, increasing risk of corticosteroid adverse effects. Dexamethasone may also reduce indinavir levels.
How serious is the interaction between Dexamethasone and Indinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for steroid adverse effects and HIV virologic response; consider a lower dexamethasone dose or shorter course.
What other medicines interact with Dexamethasone?
MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Mifepristone, Rilpivirine. The full list is on the Dexamethasone page.
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