Drug interactions
Dexamethasone + Quinupristin / dalfopristin
Severity: Moderate
Dexamethasone and Quinupristin / dalfopristin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinupristin/dalfopristin inhibits CYP3A4 and may raise dexamethasone concentrations. This could increase corticosteroid adverse effects such as hyperglycemia, fluid retention and infection risk, particularly with prolonged courses.
What this interaction means in plain words
Dexamethasone and Quinupristin / dalfopristin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated dexamethasone metabolism by quinupristin/dalfopristin.
What to do
Monitor for corticosteroid adverse effects such as glucose elevation and fluid retention during combined use. Reduce the dexamethasone dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Frequently asked questions
Can I take Dexamethasone with Quinupristin / dalfopristin?
MediHelp rates the interaction as moderate. Dexamethasone and Quinupristin / dalfopristin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinupristin/dalfopristin inhibits CYP3A4 and may raise dexamethasone concentrations. This could increase corticosteroid adverse effects such as hyperglycemia, fluid retention and infection risk, particularly with prolonged courses.
How serious is the interaction between Dexamethasone and Quinupristin / dalfopristin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid adverse effects such as glucose elevation and fluid retention during combined use. Reduce the dexamethasone dose if toxicity appears.
What other medicines interact with Dexamethasone?
MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Mifepristone, Rilpivirine. The full list is on the Dexamethasone page.
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