Drug interactions
Dexamethasone + Tezacaftor
Severity: Moderate
Dexamethasone and Tezacaftor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone may reduce tezacaftor exposure through CYP3A induction, possibly decreasing CFTR modulator efficacy. Short courses are of limited concern, but sustained use may matter.
What this interaction means in plain words
Dexamethasone and Tezacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Dexamethasone induces CYP3A4, increasing the metabolism of tezacaftor, which is a CYP3A substrate.
What to do
Monitor respiratory function and clinical response during prolonged dexamethasone courses. Avoid combining with strong inducers; consider the lowest effective steroid dose and duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Frequently asked questions
Can I take Dexamethasone with Tezacaftor?
MediHelp rates the interaction as moderate. Dexamethasone and Tezacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexamethasone may reduce tezacaftor exposure through CYP3A induction, possibly decreasing CFTR modulator efficacy. Short courses are of limited concern, but sustained use may matter.
How serious is the interaction between Dexamethasone and Tezacaftor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory function and clinical response during prolonged dexamethasone courses. Avoid combining with strong inducers; consider the lowest effective steroid dose and duration.
What other medicines interact with Dexamethasone?
MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Mifepristone, Rilpivirine. The full list is on the Dexamethasone page.
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