Drug interactions
Dexamethasone + Typhoid polysaccharide vaccine
Severity: Minor
Dexamethasone and Typhoid polysaccharide vaccine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Typhoid Vi polysaccharide vaccine is an inactivated vaccine, so it carries no risk of vaccine-strain infection. High-dose or prolonged dexamethasone may blunt the antibody response, so protection might be lower than expected.
What this interaction means in plain words
Dexamethasone and Typhoid polysaccharide vaccine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Glucocorticoid immunosuppression may reduce the antibody response to the vaccine.
What to do
Vaccination can proceed, ideally given at least 2 weeks before starting immunosuppressive corticosteroid therapy when feasible. If given during high-dose therapy, consider revaccination or checking the response after steroids are reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Frequently asked questions
Can I take Dexamethasone with Typhoid polysaccharide vaccine?
MediHelp rates the interaction as minor. Dexamethasone and Typhoid polysaccharide vaccine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Typhoid Vi polysaccharide vaccine is an inactivated vaccine, so it carries no risk of vaccine-strain infection. High-dose or prolonged dexamethasone may blunt the antibody response, so protection might be lower than expected.
How serious is the interaction between Dexamethasone and Typhoid polysaccharide vaccine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccination can proceed, ideally given at least 2 weeks before starting immunosuppressive corticosteroid therapy when feasible. If given during high-dose therapy, consider revaccination or checking the response after steroids are reduced.
What other medicines interact with Dexamethasone?
MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Mifepristone, Rilpivirine. The full list is on the Dexamethasone page.
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