Drug interactions
Dexamethasone-neomycin-polymyxin + Fentanyl transmucosal
Severity: Minor
Dexamethasone-neomycin-polymyxin and Fentanyl transmucosal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone can induce CYP3A4 and lower fentanyl levels, which may cause reduced analgesia or withdrawal. When the inducer is stopped, fentanyl levels can rise and increase respiratory depression risk. With topical or ophthalmic dexamethasone the effect is expected to be small.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Fentanyl transmucosal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Dexamethasone induces CYP3A4, increasing fentanyl clearance.
What to do
Monitor pain control and sedation if systemic dexamethasone exposure is meaningful, particularly when it is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Fentanyl transmucosal?
MediHelp rates the interaction as minor. Dexamethasone-neomycin-polymyxin and Fentanyl transmucosal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dexamethasone can induce CYP3A4 and lower fentanyl levels, which may cause reduced analgesia or withdrawal. When the inducer is stopped, fentanyl levels can rise and increase respiratory depression risk. With topical or ophthalmic dexamethasone the effect is expected to be small.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Fentanyl transmucosal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pain control and sedation if systemic dexamethasone exposure is meaningful, particularly when it is started or stopped.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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