Drug interactions
Dexamethasone-neomycin-polymyxin + Indinavir
Severity: Moderate
Dexamethasone-neomycin-polymyxin and Indinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir inhibits CYP3A4 and may raise systemic dexamethasone levels, increasing corticosteroid adverse effects. Dexamethasone induction might also lower indinavir levels, risking reduced antiviral effect.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Indinavir inhibits CYP3A4 and P-glycoprotein, reducing dexamethasone clearance, while dexamethasone may induce CYP3A4.
What to do
Monitor for corticosteroid excess and HIV viral load. Use the lowest effective dexamethasone dose and duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Indinavir?
MediHelp rates the interaction as moderate. Dexamethasone-neomycin-polymyxin and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir inhibits CYP3A4 and may raise systemic dexamethasone levels, increasing corticosteroid adverse effects. Dexamethasone induction might also lower indinavir levels, risking reduced antiviral effect.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Indinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid excess and HIV viral load. Use the lowest effective dexamethasone dose and duration.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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