Drug interactions
Dexamethasone-neomycin-polymyxin + Influenza a vaccine
Severity: Moderate
Dexamethasone-neomycin-polymyxin and Influenza a vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic corticosteroids at immunosuppressive doses can blunt the antibody response to inactivated vaccines. Topical eye or ear use has little effect on immune response.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Influenza a vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Corticosteroid-mediated immunosuppression reduces vaccine immunogenicity.
What to do
Where possible, vaccinate before starting prolonged systemic corticosteroids or at lower doses. Do not delay vaccination for topical use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Influenza a vaccine?
MediHelp rates the interaction as moderate. Dexamethasone-neomycin-polymyxin and Influenza a vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic corticosteroids at immunosuppressive doses can blunt the antibody response to inactivated vaccines. Topical eye or ear use has little effect on immune response.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Influenza a vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, vaccinate before starting prolonged systemic corticosteroids or at lower doses. Do not delay vaccination for topical use.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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