Drug interactions
Dexamethasone-neomycin-polymyxin + Influenza virus vaccine quadrivalent recombinant
Severity: Moderate
Dexamethasone-neomycin-polymyxin and Influenza virus vaccine quadrivalent recombinant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic corticosteroids at immunosuppressive doses can reduce the antibody response to influenza vaccines. Topical use has little effect.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Influenza virus vaccine quadrivalent recombinant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Corticosteroid-mediated immunosuppression reduces vaccine immunogenicity.
What to do
Vaccinate before starting prolonged systemic corticosteroids where feasible. Do not withhold vaccination solely for topical use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Influenza virus vaccine quadrivalent recombinant?
MediHelp rates the interaction as moderate. Dexamethasone-neomycin-polymyxin and Influenza virus vaccine quadrivalent recombinant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic corticosteroids at immunosuppressive doses can reduce the antibody response to influenza vaccines. Topical use has little effect.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Influenza virus vaccine quadrivalent recombinant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before starting prolonged systemic corticosteroids where feasible. Do not withhold vaccination solely for topical use.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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