Drug interactions
Dexamethasone-neomycin-polymyxin + Isoniazid
Severity: Minor
Dexamethasone-neomycin-polymyxin and Isoniazid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids may alter isoniazid acetylation and clearance, and isoniazid has been reported to affect corticosteroid metabolism. The clinical effect is unpredictable and usually small, and the legacy claim of CYP3A4 inhibition raising dexamethasone is weakly supported.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Isoniazid belongs to Anti Bacterial.
Why it happens
Possible modest changes in hepatic metabolism of both drugs; the mechanism is not firmly established.
What to do
No routine dose change is needed. Monitor for corticosteroid adverse effects and for isoniazid efficacy or hepatotoxicity during prolonged therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Other interactions of Isoniazid
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Isoniazid?
MediHelp rates the interaction as minor. Dexamethasone-neomycin-polymyxin and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Corticosteroids may alter isoniazid acetylation and clearance, and isoniazid has been reported to affect corticosteroid metabolism. The clinical effect is unpredictable and usually small, and the legacy claim of CYP3A4 inhibition raising dexamethasone is weakly supported.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Isoniazid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for corticosteroid adverse effects and for isoniazid efficacy or hepatotoxicity during prolonged therapy.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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