Drug interactions
Dexamethasone-neomycin-polymyxin + Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate
Severity: Minor
Dexamethasone-neomycin-polymyxin and Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone is a CYP3A4 inducer that could in theory lower contraceptive hormone levels. With topical or ophthalmic use the systemic induction is negligible and contraceptive failure is not expected.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Dexamethasone induces CYP3A4, which may increase metabolism of ethinylestradiol and levonorgestrel.
What to do
No additional contraception is needed for topical use; consider a backup method if prolonged high-dose systemic dexamethasone is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate?
MediHelp rates the interaction as minor. Dexamethasone-neomycin-polymyxin and Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dexamethasone is a CYP3A4 inducer that could in theory lower contraceptive hormone levels. With topical or ophthalmic use the systemic induction is negligible and contraceptive failure is not expected.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No additional contraception is needed for topical use; consider a backup method if prolonged high-dose systemic dexamethasone is used.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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