Drug interactions
Dexamethasone-neomycin-polymyxin + Lonapegsomatropin
Severity: Minor
Dexamethasone-neomycin-polymyxin and Lonapegsomatropin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone inhibits 11-beta-hydroxysteroid dehydrogenase type 1, which reduces conversion of cortisone to active cortisol. Patients on glucocorticoid replacement may therefore need higher doses after starting growth hormone. Reduced steroid effect is not expected from short topical use of this product.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Lonapegsomatropin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Lonapegsomatropin belongs to Endocrine.
Why it happens
Growth hormone inhibits 11-beta-HSD1, lowering cortisol activation and possibly the effect of cortisone-type steroids.
What to do
No action is needed for topical use. In patients on glucocorticoid replacement for hypoadrenalism, reassess dosing after starting lonapegsomatropin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Other interactions of Lonapegsomatropin
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Lonapegsomatropin?
MediHelp rates the interaction as minor. Dexamethasone-neomycin-polymyxin and Lonapegsomatropin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Growth hormone inhibits 11-beta-hydroxysteroid dehydrogenase type 1, which reduces conversion of cortisone to active cortisol. Patients on glucocorticoid replacement may therefore need higher doses after starting growth hormone. Reduced steroid effect is not expected from short topical use of this product.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Lonapegsomatropin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed for topical use. In patients on glucocorticoid replacement for hypoadrenalism, reassess dosing after starting lonapegsomatropin.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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