Drug interactions
Dexamethasone-neomycin-polymyxin + Metronidazole
Severity: Minor
Dexamethasone-neomycin-polymyxin and Metronidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metronidazole is only a weak CYP3A4 inhibitor and any rise in dexamethasone exposure is unlikely to be clinically important. Corticosteroids may lower metronidazole levels slightly through enzyme induction.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Metronidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Metronidazole belongs to Anti Parasitic.
Why it happens
Weak, poorly characterized effects on hepatic metabolism.
What to do
No dose adjustment is needed; monitor clinical response to both drugs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Metronidazole?
MediHelp rates the interaction as minor. Dexamethasone-neomycin-polymyxin and Metronidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metronidazole is only a weak CYP3A4 inhibitor and any rise in dexamethasone exposure is unlikely to be clinically important. Corticosteroids may lower metronidazole levels slightly through enzyme induction.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Metronidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor clinical response to both drugs.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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