Drug interactions
Dexamethasone-neomycin-polymyxin + Miconazole vaginal
Severity: Minor
Dexamethasone-neomycin-polymyxin and Miconazole vaginal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Miconazole inhibits CYP3A4 and can increase corticosteroid exposure, but vaginal absorption is limited and the topical dexamethasone product has low systemic levels. Clinically meaningful interaction is unlikely.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Miconazole vaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Miconazole inhibits CYP3A4, slightly reducing dexamethasone metabolism.
What to do
No action is needed for short courses. With prolonged systemic dexamethasone, monitor for steroid adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Miconazole vaginal?
MediHelp rates the interaction as minor. Dexamethasone-neomycin-polymyxin and Miconazole vaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Miconazole inhibits CYP3A4 and can increase corticosteroid exposure, but vaginal absorption is limited and the topical dexamethasone product has low systemic levels. Clinically meaningful interaction is unlikely.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Miconazole vaginal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed for short courses. With prolonged systemic dexamethasone, monitor for steroid adverse effects.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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