Drug interactions
Dexamethasone-neomycin-polymyxin + Phenindione
Severity: Moderate
Dexamethasone-neomycin-polymyxin and Phenindione: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids can alter the response to oral anticoagulants unpredictably, either reducing the effect or increasing bleeding tendency through effects on vascular integrity and the gastric mucosa. Phenindione is a vitamin K antagonist with a narrow therapeutic range, so any change in control is important.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Phenindione can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mixed pharmacodynamic effects of corticosteroids on coagulation and vascular fragility; mechanism not firmly established.
What to do
Monitor INR more frequently when systemic dexamethasone is started, changed or stopped, and adjust the phenindione dose accordingly. Topical use seldom needs extra monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Phenindione?
MediHelp rates the interaction as moderate. Dexamethasone-neomycin-polymyxin and Phenindione can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids can alter the response to oral anticoagulants unpredictably, either reducing the effect or increasing bleeding tendency through effects on vascular integrity and the gastric mucosa. Phenindione is a vitamin K antagonist with a narrow therapeutic range, so any change in control is important.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Phenindione?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR more frequently when systemic dexamethasone is started, changed or stopped, and adjust the phenindione dose accordingly. Topical use seldom needs extra monitoring.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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