Drug interactions
Dexamethasone-neomycin-polymyxin + Quinupristin / dalfopristin
Severity: Moderate
Dexamethasone-neomycin-polymyxin and Quinupristin / dalfopristin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinupristin/dalfopristin inhibits CYP3A4 and may raise dexamethasone levels, increasing the risk of corticosteroid adverse effects with systemic use. The effect is of little concern with topical dexamethasone.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Quinupristin / dalfopristin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 by quinupristin/dalfopristin reduces dexamethasone metabolism.
What to do
With systemic dexamethasone, watch for steroid excess such as hyperglycemia and fluid retention and reduce the dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Quinupristin / dalfopristin?
MediHelp rates the interaction as moderate. Dexamethasone-neomycin-polymyxin and Quinupristin / dalfopristin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinupristin/dalfopristin inhibits CYP3A4 and may raise dexamethasone levels, increasing the risk of corticosteroid adverse effects with systemic use. The effect is of little concern with topical dexamethasone.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Quinupristin / dalfopristin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With systemic dexamethasone, watch for steroid excess such as hyperglycemia and fluid retention and reduce the dose if needed.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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