Drug interactions
Dexamethasone-tobramycin + Flurbiprofen
Severity: Moderate
Dexamethasone-tobramycin and Flurbiprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a corticosteroid with an NSAID such as flurbiprofen increases the risk of gastric ulceration and bleeding. Risk rises with systemic corticosteroid use and longer treatment.
What this interaction means in plain words
Dexamethasone-tobramycin and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-tobramycin belongs to Anti Bacterial; Flurbiprofen belongs to Musculoskeletal.
Why it happens
Additive gastrointestinal mucosal injury from prostaglandin inhibition and corticosteroid-impaired healing.
What to do
Monitor for GI symptoms and bleeding, and consider a proton pump inhibitor in higher-risk patients. Keep combined therapy as short as possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Frequently asked questions
Can I take Dexamethasone-tobramycin with Flurbiprofen?
MediHelp rates the interaction as moderate. Dexamethasone-tobramycin and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a corticosteroid with an NSAID such as flurbiprofen increases the risk of gastric ulceration and bleeding. Risk rises with systemic corticosteroid use and longer treatment.
How serious is the interaction between Dexamethasone-tobramycin and Flurbiprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for GI symptoms and bleeding, and consider a proton pump inhibitor in higher-risk patients. Keep combined therapy as short as possible.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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