Drug interactions
Dexamethasone-tobramycin + Foscarnet
Severity: Moderate
Dexamethasone-tobramycin and Foscarnet: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Foscarnet and tobramycin are both nephrotoxic, and the aminoglycoside also carries ototoxic risk. Using both can cause additive kidney injury, electrolyte disturbance and renal impairment. Systemic exposure from a dexamethasone-tobramycin topical or ophthalmic product is low, but systemic tobramycin would raise the risk considerably.
What this interaction means in plain words
Dexamethasone-tobramycin and Foscarnet can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-tobramycin belongs to Anti Bacterial; Foscarnet belongs to Anti Virals.
Why it happens
Additive nephrotoxicity from two agents that each damage renal tubular cells.
What to do
If systemic tobramycin is used, monitor serum creatinine and electrolytes (calcium, magnesium, potassium) closely and keep hydration adequate. Avoid the combination where alternatives exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Frequently asked questions
Can I take Dexamethasone-tobramycin with Foscarnet?
MediHelp rates the interaction as moderate. Dexamethasone-tobramycin and Foscarnet can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Foscarnet and tobramycin are both nephrotoxic, and the aminoglycoside also carries ototoxic risk. Using both can cause additive kidney injury, electrolyte disturbance and renal impairment. Systemic exposure from a dexamethasone-tobramycin topical or ophthalmic product is low, but systemic tobramycin would raise the risk considerably.
How serious is the interaction between Dexamethasone-tobramycin and Foscarnet?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If systemic tobramycin is used, monitor serum creatinine and electrolytes (calcium, magnesium, potassium) closely and keep hydration adequate. Avoid the combination where alternatives exist.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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