Drug interactions
Dexamethasone-tobramycin + Imipramine
Severity: Minor
Dexamethasone-tobramycin and Imipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone may modestly increase CYP3A4-mediated metabolism of imipramine. Imipramine is also cleared by CYP2C19 and CYP2D6, so the effect is probably small.
What this interaction means in plain words
Dexamethasone-tobramycin and Imipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexamethasone-tobramycin belongs to Anti Bacterial; Imipramine belongs to Central Nervous System.
Why it happens
CYP3A4 induction by dexamethasone may increase imipramine metabolism.
What to do
No routine adjustment is needed; reassess antidepressant response if systemic steroid therapy is prolonged.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Dexamethasone-tobramycin with Imipramine?
MediHelp rates the interaction as minor. Dexamethasone-tobramycin and Imipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dexamethasone may modestly increase CYP3A4-mediated metabolism of imipramine. Imipramine is also cleared by CYP2C19 and CYP2D6, so the effect is probably small.
How serious is the interaction between Dexamethasone-tobramycin and Imipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; reassess antidepressant response if systemic steroid therapy is prolonged.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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