Drug interactions
Dexamethasone-tobramycin + Ivosidenib
Severity: Moderate
Dexamethasone-tobramycin and Ivosidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4 and may lower dexamethasone exposure, reducing its anti-inflammatory or antiemetic effect. The impact is limited with topical or ophthalmic dexamethasone, which acts locally.
What this interaction means in plain words
Dexamethasone-tobramycin and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-tobramycin belongs to Anti Bacterial; Ivosidenib belongs to Oncology.
Why it happens
Ivosidenib induces CYP3A4, increasing dexamethasone clearance.
What to do
If systemic dexamethasone is needed, monitor for loss of effect and consider a higher dose or an alternative; ivosidenib labeling also notes QT prolongation to be monitored.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dexamethasone-tobramycin and Ivosidenib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dexamethasone-tobramycin
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Dexamethasone-tobramycin with Ivosidenib?
MediHelp rates the interaction as moderate. Dexamethasone-tobramycin and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib induces CYP3A4 and may lower dexamethasone exposure, reducing its anti-inflammatory or antiemetic effect. The impact is limited with topical or ophthalmic dexamethasone, which acts locally.
How serious is the interaction between Dexamethasone-tobramycin and Ivosidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If systemic dexamethasone is needed, monitor for loss of effect and consider a higher dose or an alternative; ivosidenib labeling also notes QT prolongation to be monitored.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
