Drug interactions
Dexamethasone-tobramycin + Quinine
Severity: Minor
Dexamethasone-tobramycin and Quinine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinine is metabolized mainly by CYP3A4, so dexamethasone induction could lower quinine concentrations and potentially reduce antimalarial efficacy. The effect is mostly of concern with prolonged systemic steroid use.
What this interaction means in plain words
Dexamethasone-tobramycin and Quinine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexamethasone-tobramycin belongs to Anti Bacterial; Quinine belongs to Anti Parasitic.
Why it happens
CYP3A4 induction by dexamethasone increases quinine clearance.
What to do
Monitor clinical response to quinine treatment when systemic dexamethasone is co-administered.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Frequently asked questions
Can I take Dexamethasone-tobramycin with Quinine?
MediHelp rates the interaction as minor. Dexamethasone-tobramycin and Quinine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quinine is metabolized mainly by CYP3A4, so dexamethasone induction could lower quinine concentrations and potentially reduce antimalarial efficacy. The effect is mostly of concern with prolonged systemic steroid use.
How serious is the interaction between Dexamethasone-tobramycin and Quinine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to quinine treatment when systemic dexamethasone is co-administered.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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