Drug interactions
Dexamethasone-tobramycin + Somatrogon
Severity: Moderate
Dexamethasone-tobramycin and Somatrogon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Supraphysiologic glucocorticoid exposure can reduce the growth-promoting effect of growth hormone analogs, and growth hormone can lower cortisol activation through 11-beta-HSD1 inhibition. Patients on glucocorticoid replacement may need dose adjustments after somatrogon is started.
What this interaction means in plain words
Dexamethasone-tobramycin and Somatrogon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-tobramycin belongs to Anti Bacterial; Somatrogon belongs to Endocrine.
Why it happens
Glucocorticoid antagonism of growth hormone effects and growth hormone inhibition of 11-beta-HSD1.
What to do
Use the lowest effective glucocorticoid dose and monitor growth velocity. Review glucocorticoid replacement needs after initiating somatrogon.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dexamethasone-tobramycin and Somatrogon, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dexamethasone-tobramycin
Other interactions of Somatrogon
- Alogliptin-metformin + Somatrogon Moderate
- Alogliptin-pioglitazone + Somatrogon Moderate
- Alogliptin + Somatrogon Moderate
- Canagliflozin-metformin + Somatrogon Moderate
- Chlorpropamide + Somatrogon Moderate
- Cyclosporin + Somatrogon Moderate
Frequently asked questions
Can I take Dexamethasone-tobramycin with Somatrogon?
MediHelp rates the interaction as moderate. Dexamethasone-tobramycin and Somatrogon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Supraphysiologic glucocorticoid exposure can reduce the growth-promoting effect of growth hormone analogs, and growth hormone can lower cortisol activation through 11-beta-HSD1 inhibition. Patients on glucocorticoid replacement may need dose adjustments after somatrogon is started.
How serious is the interaction between Dexamethasone-tobramycin and Somatrogon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective glucocorticoid dose and monitor growth velocity. Review glucocorticoid replacement needs after initiating somatrogon.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
