Drug interactions
Dexamethasone-tobramycin + Streptomycin
Severity: Major
Dexamethasone-tobramycin and Streptomycin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Streptomycin and tobramycin are both aminoglycosides with nephrotoxic, ototoxic and neuromuscular blocking potential. Combining them systemically adds to these risks and can cause irreversible hearing or vestibular damage.
What this interaction means in plain words
Dexamethasone-tobramycin and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dexamethasone-tobramycin belongs to Anti Bacterial; Streptomycin belongs to Anti Bacterial.
Why it happens
Additive aminoglycoside accumulation in renal tubular cells and inner ear hair cells causes additive toxicity.
What to do
Avoid concurrent systemic use of two aminoglycosides. If unavoidable, monitor renal function, drug levels and auditory and vestibular function closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dexamethasone-tobramycin
Other interactions of Streptomycin
Frequently asked questions
Can I take Dexamethasone-tobramycin with Streptomycin?
MediHelp rates the interaction as major. Dexamethasone-tobramycin and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Streptomycin and tobramycin are both aminoglycosides with nephrotoxic, ototoxic and neuromuscular blocking potential. Combining them systemically adds to these risks and can cause irreversible hearing or vestibular damage.
How serious is the interaction between Dexamethasone-tobramycin and Streptomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent systemic use of two aminoglycosides. If unavoidable, monitor renal function, drug levels and auditory and vestibular function closely.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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