Drug interactions
Dexamethasone-tobramycin + Tolmetin
Severity: Moderate
Dexamethasone-tobramycin and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a corticosteroid with an NSAID raises the risk of peptic ulcers and gastrointestinal bleeding. NSAIDs may also add to renal toxicity when tobramycin is given systemically.
What this interaction means in plain words
Dexamethasone-tobramycin and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-tobramycin belongs to Anti Bacterial; Tolmetin belongs to Musculoskeletal.
Why it happens
Additive gastric mucosal injury from prostaglandin inhibition and corticosteroid effects.
What to do
Use the lowest effective doses for the shortest time and add a proton pump inhibitor in at-risk patients. Monitor renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Frequently asked questions
Can I take Dexamethasone-tobramycin with Tolmetin?
MediHelp rates the interaction as moderate. Dexamethasone-tobramycin and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a corticosteroid with an NSAID raises the risk of peptic ulcers and gastrointestinal bleeding. NSAIDs may also add to renal toxicity when tobramycin is given systemically.
How serious is the interaction between Dexamethasone-tobramycin and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest time and add a proton pump inhibitor in at-risk patients. Monitor renal function.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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