Drug interactions
Dexamethasone-tobramycin + Ublituximab
Severity: Moderate
Dexamethasone-tobramycin and Ublituximab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ublituximab depletes B cells, and systemic corticosteroids add immunosuppression, raising infection risk. Dexamethasone is also used as premedication for infusion reactions, which is accepted practice. Ophthalmic use adds little systemic effect.
What this interaction means in plain words
Dexamethasone-tobramycin and Ublituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-tobramycin belongs to Anti Bacterial; Ublituximab belongs to Miscellaneous.
Why it happens
Additive immunosuppression from B-cell depletion and glucocorticoid effects.
What to do
Dexamethasone premedication for infusions is acceptable. Monitor for infections during prolonged systemic steroid use alongside ublituximab.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Ublituximab
Frequently asked questions
Can I take Dexamethasone-tobramycin with Ublituximab?
MediHelp rates the interaction as moderate. Dexamethasone-tobramycin and Ublituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ublituximab depletes B cells, and systemic corticosteroids add immunosuppression, raising infection risk. Dexamethasone is also used as premedication for infusion reactions, which is accepted practice. Ophthalmic use adds little systemic effect.
How serious is the interaction between Dexamethasone-tobramycin and Ublituximab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Dexamethasone premedication for infusions is acceptable. Monitor for infections during prolonged systemic steroid use alongside ublituximab.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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