Drug interactions
Fingolimod + Ublituximab
Severity: Major
Fingolimod and Ublituximab: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ublituximab depletes B cells for a prolonged period and fingolimod reduces circulating lymphocytes. Combined or sequential use may increase the risk of serious infection.
What this interaction means in plain words
Fingolimod and Ublituximab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fingolimod belongs to Central Nervous System; Ublituximab belongs to Miscellaneous.
Why it happens
Additive immunosuppression through B-cell depletion and lymphocyte sequestration.
What to do
Avoid concurrent use. When switching between them, account for the prolonged effect of ublituximab and monitor lymphocyte counts and infections.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Other interactions of Ublituximab
Frequently asked questions
Can I take Fingolimod with Ublituximab?
MediHelp rates the interaction as major. Fingolimod and Ublituximab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ublituximab depletes B cells for a prolonged period and fingolimod reduces circulating lymphocytes. Combined or sequential use may increase the risk of serious infection.
How serious is the interaction between Fingolimod and Ublituximab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use. When switching between them, account for the prolonged effect of ublituximab and monitor lymphocyte counts and infections.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
Full monographs, dosing and an interaction checker in the MediHelp app
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