Drug interactions
Dexfenfluramine + Frovatriptan
Severity: Moderate
Dexfenfluramine and Frovatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexfenfluramine releases serotonin and blocks its reuptake, while frovatriptan directly stimulates serotonin receptors. Combining them may increase the risk of serotonin syndrome.
What this interaction means in plain words
Dexfenfluramine and Frovatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effect through serotonin release and reuptake inhibition plus receptor agonism.
What to do
Monitor for signs of serotonin toxicity such as agitation, tremor, diarrhea and hyperthermia. Consider an alternative migraine therapy if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Frequently asked questions
Can I take Dexfenfluramine with Frovatriptan?
MediHelp rates the interaction as moderate. Dexfenfluramine and Frovatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexfenfluramine releases serotonin and blocks its reuptake, while frovatriptan directly stimulates serotonin receptors. Combining them may increase the risk of serotonin syndrome.
How serious is the interaction between Dexfenfluramine and Frovatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin toxicity such as agitation, tremor, diarrhea and hyperthermia. Consider an alternative migraine therapy if symptoms occur.
What other medicines interact with Frovatriptan?
MediHelp also lists interactions of Frovatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Frovatriptan page.
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