Drug interactions
Dexfenfluramine + Insulin glargine-lixisenatide
Severity: Moderate
Dexfenfluramine and Insulin glargine-lixisenatide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexfenfluramine may enhance peripheral glucose uptake and add to the effect of insulin. This can increase the risk of hypoglycemia.
What this interaction means in plain words
Dexfenfluramine and Insulin glargine-lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Increased peripheral glucose uptake produces an additive glucose-lowering effect.
What to do
Monitor blood glucose and reduce the insulin dose if hypoglycemia occurs. Note that dexfenfluramine has been withdrawn in most markets.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Frequently asked questions
Can I take Dexfenfluramine with Insulin glargine-lixisenatide?
MediHelp rates the interaction as moderate. Dexfenfluramine and Insulin glargine-lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexfenfluramine may enhance peripheral glucose uptake and add to the effect of insulin. This can increase the risk of hypoglycemia.
How serious is the interaction between Dexfenfluramine and Insulin glargine-lixisenatide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and reduce the insulin dose if hypoglycemia occurs. Note that dexfenfluramine has been withdrawn in most markets.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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