Drug interactions
Dexfenfluramine + Pseudoephedrine
Severity: Moderate
Dexfenfluramine and Pseudoephedrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Co-administration may add to adrenergic and serotonergic stimulation, raising blood pressure and heart rate. Dexfenfluramine has been withdrawn in most markets, so this is mostly of historical relevance.
What this interaction means in plain words
Dexfenfluramine and Pseudoephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sympathomimetic effects; dexfenfluramine mainly releases serotonin while pseudoephedrine releases norepinephrine.
What to do
Monitor blood pressure and heart rate if the combination cannot be avoided. Prefer a non-sympathomimetic decongestant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pseudoephedrine
- Isocarboxazid + Pseudoephedrine Contraindicated
- Phenelzine + Pseudoephedrine Contraindicated
- Pseudoephedrine + Rasagiline Contraindicated
- Pseudoephedrine + Selegiline Contraindicated
- Pseudoephedrine + Selegiline transdermal Contraindicated
- Pseudoephedrine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Dexfenfluramine with Pseudoephedrine?
MediHelp rates the interaction as moderate. Dexfenfluramine and Pseudoephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Co-administration may add to adrenergic and serotonergic stimulation, raising blood pressure and heart rate. Dexfenfluramine has been withdrawn in most markets, so this is mostly of historical relevance.
How serious is the interaction between Dexfenfluramine and Pseudoephedrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate if the combination cannot be avoided. Prefer a non-sympathomimetic decongestant.
What other medicines interact with Pseudoephedrine?
MediHelp also lists interactions of Pseudoephedrine with, for example, Isocarboxazid, Phenelzine, Rasagiline. The full list is on the Pseudoephedrine page.
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