Drug interactions
Pseudoephedrine + Rasagiline
Severity: Contraindicated
Pseudoephedrine and Rasagiline: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rasagiline inhibits MAO-B and at higher doses loses selectivity, which can allow an exaggerated pressor response to indirect sympathomimetics such as pseudoephedrine. Labeling advises against the combination because of hypertensive crisis reports.
What this interaction means in plain words
Pseudoephedrine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pseudoephedrine belongs to Respiratory; Rasagiline belongs to Central Nervous System.
Why it happens
MAO inhibition potentiates norepinephrine release caused by pseudoephedrine, producing additive pressor effects.
What to do
Do not co-administer; use non-sympathomimetic alternatives for nasal congestion. If taken inadvertently, monitor blood pressure and treat hypertension urgently.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Pseudoephedrine
- Isocarboxazid + Pseudoephedrine Contraindicated
- Phenelzine + Pseudoephedrine Contraindicated
- Pseudoephedrine + Selegiline Contraindicated
- Pseudoephedrine + Selegiline transdermal Contraindicated
- Pseudoephedrine + Tranylcypromine Contraindicated
- Benzphetamine + Pseudoephedrine Major
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Pseudoephedrine with Rasagiline?
MediHelp rates the interaction as contraindicated. Pseudoephedrine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rasagiline inhibits MAO-B and at higher doses loses selectivity, which can allow an exaggerated pressor response to indirect sympathomimetics such as pseudoephedrine. Labeling advises against the combination because of hypertensive crisis reports.
How serious is the interaction between Pseudoephedrine and Rasagiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; use non-sympathomimetic alternatives for nasal congestion. If taken inadvertently, monitor blood pressure and treat hypertension urgently.
What other medicines interact with Pseudoephedrine?
MediHelp also lists interactions of Pseudoephedrine with, for example, Isocarboxazid, Phenelzine, Selegiline. The full list is on the Pseudoephedrine page.
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