Drug interactions
Dextroamphetamine + Doxapram
Severity: Major
Dextroamphetamine and Doxapram: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs stimulate the sympathetic and central nervous systems and can raise blood pressure and heart rate. Taken together they may cause marked hypertension, arrhythmias and CNS excitation, including agitation or seizures.
What this interaction means in plain words
Dextroamphetamine and Doxapram can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dextroamphetamine belongs to Central Nervous System; Doxapram belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic pressor and CNS stimulant effects.
What to do
Avoid the combination where an alternative exists. If doxapram is essential, monitor blood pressure, heart rhythm and neurological status continuously.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Other interactions of Doxapram
- Desflurane + Doxapram Major
- Doxapram + Isocarboxazid Major
- Doxapram + Ketamine Major
- Doxapram + Linezolid Major
- Doxapram + Lisdexamfetamine Major
- Doxapram + Methamphetamine Major
Frequently asked questions
Can I take Dextroamphetamine with Doxapram?
MediHelp rates the interaction as major. Dextroamphetamine and Doxapram can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs stimulate the sympathetic and central nervous systems and can raise blood pressure and heart rate. Taken together they may cause marked hypertension, arrhythmias and CNS excitation, including agitation or seizures.
How serious is the interaction between Dextroamphetamine and Doxapram?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where an alternative exists. If doxapram is essential, monitor blood pressure, heart rhythm and neurological status continuously.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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