Drug interactions
Doxapram + Methamphetamine
Severity: Major
Doxapram and Methamphetamine: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs stimulate the sympathetic and central nervous systems. Together they may cause marked hypertension, arrhythmia and CNS excitation, including agitation or seizures.
What this interaction means in plain words
Doxapram and Methamphetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Doxapram belongs to Central Nervous System; Methamphetamine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic pressor and CNS stimulant effects.
What to do
Avoid if an alternative exists. If doxapram is essential, monitor blood pressure, heart rhythm and neurological status continuously.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Other interactions of Doxapram
- Desflurane + Doxapram Major
- Dextroamphetamine + Doxapram Major
- Doxapram + Isocarboxazid Major
- Doxapram + Ketamine Major
- Doxapram + Linezolid Major
- Doxapram + Lisdexamfetamine Major
Frequently asked questions
Can I take Doxapram with Methamphetamine?
MediHelp rates the interaction as major. Doxapram and Methamphetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs stimulate the sympathetic and central nervous systems. Together they may cause marked hypertension, arrhythmia and CNS excitation, including agitation or seizures.
How serious is the interaction between Doxapram and Methamphetamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if an alternative exists. If doxapram is essential, monitor blood pressure, heart rhythm and neurological status continuously.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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