Drug interactions
Dextroamphetamine + Fluticasone-salmeterol
Severity: Moderate
Dextroamphetamine and Fluticasone-salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dextroamphetamine is a sympathomimetic that raises heart rate and blood pressure, and salmeterol adds beta-adrenergic stimulation. Together they may cause tachycardia, palpitations, tremor and hypertension, especially in patients with cardiovascular disease.
What this interaction means in plain words
Dextroamphetamine and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dextroamphetamine belongs to Central Nervous System; Fluticasone-salmeterol belongs to Respiratory.
Why it happens
Additive sympathomimetic effects from amphetamine-induced catecholamine release and direct beta-2 agonism.
What to do
Monitor heart rate and blood pressure and watch for palpitations or arrhythmia. Reassess the need for either drug in patients with cardiovascular disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Fluticasone-salmeterol?
MediHelp rates the interaction as moderate. Dextroamphetamine and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dextroamphetamine is a sympathomimetic that raises heart rate and blood pressure, and salmeterol adds beta-adrenergic stimulation. Together they may cause tachycardia, palpitations, tremor and hypertension, especially in patients with cardiovascular disease.
How serious is the interaction between Dextroamphetamine and Fluticasone-salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure and watch for palpitations or arrhythmia. Reassess the need for either drug in patients with cardiovascular disease.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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