Drug interactions
Dextroamphetamine + Frovatriptan
Severity: Moderate
Dextroamphetamine and Frovatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamines release serotonin and norepinephrine, and triptans are serotonin 5-HT1B/1D agonists, so combined use could add to serotonergic and vasoconstrictive effects. Serotonin syndrome and blood pressure elevation are possible but reported rarely.
What this interaction means in plain words
Dextroamphetamine and Frovatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dextroamphetamine belongs to Central Nervous System; Frovatriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic and vasopressor activity from amphetamine-induced monoamine release plus triptan agonism.
What to do
Monitor for agitation, tremor, hyperthermia, diarrhea and elevated blood pressure, and counsel the patient to seek care if these appear after a triptan dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Frovatriptan?
MediHelp rates the interaction as moderate. Dextroamphetamine and Frovatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphetamines release serotonin and norepinephrine, and triptans are serotonin 5-HT1B/1D agonists, so combined use could add to serotonergic and vasoconstrictive effects. Serotonin syndrome and blood pressure elevation are possible but reported rarely.
How serious is the interaction between Dextroamphetamine and Frovatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperthermia, diarrhea and elevated blood pressure, and counsel the patient to seek care if these appear after a triptan dose.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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