Drug interactions
Dextroamphetamine + Hydralazine
Severity: Moderate
Dextroamphetamine and Hydralazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dextroamphetamine raises blood pressure and heart rate and can oppose the antihypertensive effect of hydralazine. Reflex tachycardia from hydralazine may also add to stimulant effects.
What this interaction means in plain words
Dextroamphetamine and Hydralazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dextroamphetamine belongs to Central Nervous System; Hydralazine belongs to Cardiovascular.
Why it happens
Pharmacodynamic antagonism: sympathomimetic-induced vasoconstriction and cardiac stimulation oppose vasodilation.
What to do
Monitor blood pressure and heart rate and adjust the antihypertensive regimen if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Hydralazine?
MediHelp rates the interaction as moderate. Dextroamphetamine and Hydralazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dextroamphetamine raises blood pressure and heart rate and can oppose the antihypertensive effect of hydralazine. Reflex tachycardia from hydralazine may also add to stimulant effects.
How serious is the interaction between Dextroamphetamine and Hydralazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and adjust the antihypertensive regimen if control is lost.
What other medicines interact with Hydralazine?
MediHelp also lists interactions of Hydralazine with, for example, Amifostine, Aceclofenac, Acemetacin. The full list is on the Hydralazine page.
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