Drug interactions
Dextroamphetamine + Imipramine
Severity: Major
Dextroamphetamine and Imipramine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclics may potentiate the cardiovascular effects of amphetamines, with hypertension, tachycardia and arrhythmia. Amphetamines may also raise tricyclic brain levels, and some serotonergic effects are possible.
What this interaction means in plain words
Dextroamphetamine and Imipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dextroamphetamine belongs to Central Nervous System; Imipramine belongs to Central Nervous System.
Why it happens
Blocked noradrenaline reuptake and altered amphetamine disposition add to sympathomimetic effect, with possible CYP2D6 effects.
What to do
Avoid if possible; otherwise monitor blood pressure, heart rate and ECG. Use low doses and watch for agitation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Imipramine?
MediHelp rates the interaction as major. Dextroamphetamine and Imipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tricyclics may potentiate the cardiovascular effects of amphetamines, with hypertension, tachycardia and arrhythmia. Amphetamines may also raise tricyclic brain levels, and some serotonergic effects are possible.
How serious is the interaction between Dextroamphetamine and Imipramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise monitor blood pressure, heart rate and ECG. Use low doses and watch for agitation.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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