Drug interactions
Dextroamphetamine + Isoflurane
Severity: Moderate
Dextroamphetamine and Isoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamines increase catecholamine release, and volatile anesthetics can sensitize the myocardium to catecholamines. During anesthesia this may result in hypertension, tachycardia or ventricular arrhythmias, although the data are limited and often extrapolated.
What this interaction means in plain words
Dextroamphetamine and Isoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dextroamphetamine belongs to Central Nervous System; Isoflurane belongs to Central Nervous System.
Why it happens
Pharmacodynamic additive sympathomimetic effects with anesthetic-related myocardial sensitization to catecholamines.
What to do
Inform the anesthesia team of recent stimulant use and monitor blood pressure and ECG continuously. Treat hemodynamic surges per standard practice and consider holding the stimulant on the day of surgery per institutional protocol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Other interactions of Isoflurane
Frequently asked questions
Can I take Dextroamphetamine with Isoflurane?
MediHelp rates the interaction as moderate. Dextroamphetamine and Isoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphetamines increase catecholamine release, and volatile anesthetics can sensitize the myocardium to catecholamines. During anesthesia this may result in hypertension, tachycardia or ventricular arrhythmias, although the data are limited and often extrapolated.
How serious is the interaction between Dextroamphetamine and Isoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of recent stimulant use and monitor blood pressure and ECG continuously. Treat hemodynamic surges per standard practice and consider holding the stimulant on the day of surgery per institutional protocol.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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