Drug interactions
Dextroamphetamine + Isoproterenol
Severity: Major
Dextroamphetamine and Isoproterenol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents stimulate the adrenergic system, dextroamphetamine through indirect release of catecholamines and isoproterenol through direct beta-agonism. Together they may cause marked tachycardia, arrhythmias and blood pressure changes.
What this interaction means in plain words
Dextroamphetamine and Isoproterenol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dextroamphetamine belongs to Central Nervous System; Isoproterenol belongs to Respiratory.
Why it happens
Additive sympathomimetic activity, indirect from amphetamine and direct beta-adrenergic agonism from isoproterenol.
What to do
Avoid the combination where possible; if isoproterenol is required, monitor continuous ECG and blood pressure and consider holding the stimulant.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Other interactions of Isoproterenol
Frequently asked questions
Can I take Dextroamphetamine with Isoproterenol?
MediHelp rates the interaction as major. Dextroamphetamine and Isoproterenol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents stimulate the adrenergic system, dextroamphetamine through indirect release of catecholamines and isoproterenol through direct beta-agonism. Together they may cause marked tachycardia, arrhythmias and blood pressure changes.
How serious is the interaction between Dextroamphetamine and Isoproterenol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if isoproterenol is required, monitor continuous ECG and blood pressure and consider holding the stimulant.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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